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View Full Version : Methatrexate Injections and Ulcers



Melodyroseak
11-28-2011, 10:21 PM
I get .6 methatrexate injections twice a week. My husband gives them to me actually. And I have really severe mouth ulcers. Was wondering if anyone else has had this problem with either the injection or Lupus itself?

They are talking about taking me off the methatrexate and putting me in that new Lupus drug Bynlista (sp). Not sure which of the two would be the worst.

Sure would like to hear from others that may have had this problem. They have tried just about every thing to get rid of them. Nothing works so far.

BonusMom
11-28-2011, 10:41 PM
I get mouth ulcers when my WBC's are low. My rheumy has given a prescription for 1 MG of Folic Acid, with the instruction that I take up to four per day (depending on the amount of mouth sores). It's very inexpensive.

magistramarla
11-29-2011, 10:26 PM
Melody,
As BonusMom said, it is very important to take folic acid while you are taking MTX. While I was taking it, all of my skin issues and sores cleared up.
Now that I am off of it, I'm getting my weird little skin issues back.
Hugs,
Marla

Melodyroseak
11-29-2011, 10:57 PM
I take 1 mg twice a day. But rhumey told me not to take the folic acid on the days of my injections. But, I thought I was on the highest amount of folic that I could take. Put a call to Dr. today, hoping to hear from him tomorrow.

Thank you for the info. So much to learn still about lupus, after 15 years.

Melody

debbie-b
11-30-2011, 07:19 AM
It is the first time, that I hear somebody injecting MTX TWICE a week. Why do you inject twice? The norm is once a week.
I am like Marla, I have less of the mouth sores, when I am taking MTX, than without it.

Debbie

tgal
11-30-2011, 09:51 AM
I take MTX pills but Ido know that it is like any other kind of chemo and it can cause mouth ulcers however I get mouth ulcers when I am about to or am going into a flare. Mouth and nose ulcers are a Lupus symptom so it could be from the meds or the disease. Listen about the Folic Acid and talk to your doctor.

steve.b
11-30-2011, 06:06 PM
in australia, the normal amount of folic acid, in pill form, is 5mg.
i was told to take it between 3 and 6 days per week.
never on mtx day.

that is 30mg per week when in flare,
and 15mg for maintenance.

my suggestion is talk to your doc about increasing.

Jaime Bea
12-01-2011, 07:24 AM
Very interesting y'all!

I take 2 mg of Folic acid every day. I do take it on my injection days, is there a reason why you shouldn't take it the day of your injection? Sense upping my dose of Folic acid I haven't been as sick as I was on 1mg. Although I am still wiped out for two days.

steve.b
12-02-2011, 12:32 AM
.... is there a reason why you shouldn't take it the day of your injection?....
the folic acid creates a chemical reaction both with your body and the methotrexate.
it deminishes and alters the effect mtx has on ytour body.

my rhumi told me that i was better off not taking the folic acid, rather than taking both.
he was very insistant on it.

magistramarla
12-03-2011, 07:46 PM
the folic acid creates a chemical reaction both with your body and the methotrexate.
it deminishes and alters the effect mtx has on ytour body.

my rhumi told me that i was better off not taking the folic acid, rather than taking both.
he was very insistant on it.

Wow, I was never told that, and I took my folic acid on the day of my injection. That is interesting to find out now.
Hugs,
Marla

Melodyroseak
12-14-2011, 04:47 PM
Sorry I did respond sooner. Been under the weather and not on my computer very much. I do 2 injections a week because I was in so much pain, they decided to split it up and take twice a week. Which really made a difference. And increasing my folic acid THANK YOU all for the information on you gave about you and how you take it. I called my rhemy and he called yesterday and said that I can increase my folic acid. I told him about the post here and he was glad I found this board.

I can not remember why they said not to take the folic acid on mtx day, but, he was my 3rd rhemy to tell me that. I had to fly out of state for years, since, Alaska did not have any here. The second one went to a different facility and didn't follow and now, am on my 3rd.